We are seeking a dedicated Scientist to join our Cancer Biomarker Development (CBD) ctDNA Team in Waltham, MA. This is an exciting opportunity to be part of an elite center for innovative cancer research and play a key role in generating genomics data to support early oncology clinical trials.In this role, you will:<ul><li>Use innovative molecular biology techniques to enable decision-making in Translational Medicine (TM) and CBD</li><li>Engage with TM and CBD colleagues to explore opportunities for novel biomarker analysis</li><li>Contribute to understanding response and resistance mechanisms in cancer therapy</li><li>Work with liquid biopsy technologies for response monitoring, minimal residual disease (MRD), and early cancer detection</li></ul>The CBD ctDNA Team focuses on identifying, evaluating, and deploying liquid biopsy tools for oncology projects. You will be involved in analyzing disease-specific patient samples, generating contrived reference samples (Stetson JCO’24), and collaborating with external partners, service providers, and academic institutions.Key ResponsibilitiesClinical and Translational Science Contributions<ul><li>Support MATRIX studies to evaluate liquid biopsy assays for early oncology clinical trials</li><li>Collaborate with ctDNA technology leads, Translational Medicine Leads (TMLs), and Precision Medicine teams</li><li>Develop and implement biomarker plans aligned with clinical study needs</li><li>Assist with assay development, troubleshooting, and optimization in partner laboratories</li><li>Generate genomics data using techniques such as panel NGS, whole exome sequencing (WES), whole genome sequencing (WGS), digital PCR, and automation</li><li>Work with internal and external partners to deliver high-quality diagnostic assay data</li></ul>Technical and Laboratory Responsibilities<ul><li>Procure and track commercial cancer patient samples using human biospecimen (HBS) tracking</li><li>Support the evaluation, selection, and partnership with third-party diagnostic labs</li><li>Implement and validate new genomics technologies within internal labs</li><li>Maintain compliance with CAP/CLIA regulations for assay validation</li><li>Record, analyze, and interpret data using LIMS, bioinformatics tools, and production informatics systems</li><li>Ensure high data quality, documentation accuracy, and adherence to regulatory guidelines</li></ul>Collaboration and Project Management<ul><li>Assist in Statements of Work (SOW) development for exploratory biomarker analyses</li><li>Manage external partnerships for biomarker sample analysis and diagnostics</li><li>Track, lead, and report on progress using laboratory tracking tools</li><li>Communicate findings effectively to internal teams, leadership, and cross-functional partners</li></ul>People Management Responsibility<ul><li>Direct Reports: None</li><li>Matrix Management: None</li><li>Team Management: None</li></ul>Why Join Us?AstraZeneca is a global leader in oncology research, committed to redefining patient outcomes through innovative translational science. Join us in shaping the future of precision medicine and cancer biomarker development.Why AstraZeneca? &nbsp;At AstraZeneca, we embrace opportunities for change to drive meaningful advancements. Our mission is clear: to deliver life-changing medicines and redefine possibilities in biopharma. By combining diverse perspectives, pioneering science, and bold ideas, we are transforming patient outcomes worldwide.Where You Can Learn More·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <a rel="noopener noreferrer" target="_blank" href="https://www.linkedin.com/company/1603/">Follow AstraZeneca on LinkedIn</a>·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <a rel="noopener noreferrer" target="_blank" href="https://www.facebook.com/astrazenecacareers/">Follow AstraZeneca on Facebook</a>·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <a rel="noopener noreferrer" target="_blank" href="https://www.instagram.com/astrazeneca_careers/?hl=en">Follow AstraZeneca on Instagram</a>Benefits We offer a competitive Total Reward program, including:·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Competitive base salary, annual bonus, and long-term incentives·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Generous paid time off program·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Comprehensive benefits packageDiversity and Inclusion at AstraZeneca AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive team that represents a diverse group of backgrounds and perspectives, knowing that inclusion drives better outcomes.We welcome all qualified candidates and align with applicable laws regarding inclusivity and employment eligibility. Individuals with disabilities can request reasonable accommodations during the application or interview process, as well as for essential job functions.Date Posted30-Jan-2025Closing Date21-Feb-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

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AstraZeneca

AstraZeneca, a global leader in oncology research, seeks a dedicated Scientist for a full-time role in Cancer Biomarker Development. The candidate should have expertise in molecular biology and genomics. Responsibilities include biomarker analysis and collaboration with partners. We offer a competitive salary, bonus, paid time off, and comprehensive benefits.

Scientist Cancer Biomarker Development

Summary